![]() ![]() In actuality, there are some elements of the peripheral nervous system that are within the cranial or vertebral cavities. Image analysis software is an essential tool used in neuroscience and neural engineering to evaluate changes in neuronal structure following extracellular stimuli. It is a bit of an oversimplification to say that the CNS is what is inside these two cavities and the peripheral nervous system is outside of them, but that is one way to start to think about it. ![]() We identified morphological variations of somata, dendrites and axons across laminar layers and PFC subregions and the general rules of somatodendritic scaling with cytoarchitecture. Cajal established the foundation for the neuron doctrine by suggesting dendrites to be the synaptic input regions of neurons, and. Here we report the complete dendrite and axon morphology of nearly 2,000 neurons in mouse prefrontal cortex (PFC). Together, our study provides a comprehensive structural repertoire for the reconstruction and analysis of PFC neural network. Already around 1900 the Spanish neuroanatomist Ramn y Cajal proposed that neurons possess two discrete functional domains, the axonal and the somatodendritic compartment. Finally, integrative dendrite-axon analysis uncovered the organization of potential intra-column, inter-hemispheric and inter-column connectivity among projection neuron types in PFC. Dendrites are structural ramifications of a neuron specialized for receiving and processing synaptic input ( 1 ). The brain is contained within the cranial cavity of the skull, and the spinal cord is contained within the vertebral cavity of the vertebral column. Neurons represent the cellular substrate for information processing in the nervous system.
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